Staging TDP-43 pathology in Alzheimer’s disease

  title={Staging TDP-43 pathology in Alzheimer’s disease},
  author={Keith A. Josephs and Melissa E. Murray and Jennifer L. Whitwell and Joseph E. Parisi and Leonard Petrucelli and Clifford R. Jack and Ronald C. Petersen and Dennis W. Dickson},
  journal={Acta Neuropathologica},
TDP-43 immunoreactivity occurs in 19–57 % of Alzheimer’s disease (AD) cases. Two patterns of TDP-43 deposition in AD have been described involving hippocampus (limbic) or hippocampus and neocortex (diffuse), although focal amygdala involvement has been observed. In 195 AD cases with TDP-43, we investigated regional TDP-43 immunoreactivity with the aim of developing a TDP-43 in AD staging scheme. TDP-43 immunoreactivity was assessed in amygdala, entorhinal cortex, subiculum, hippocampal dentate… CONTINUE READING


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The Boston Naming Test. Veterans Administration Medical Center, City

  • E Kaplan, H Goodglass, S Weintraub
  • 1978
Highly Influential
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