Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.

  title={Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.},
  author={Johannes Brettschneider and Kelly del Tredici and Jon B. Toledo and John L. Robinson and David John Irwin and Murray Grossman and Eunran Suh and Vivianna M Van Deerlin and Elisabeth McCarty Wood and Young Jin Baek and Linda K. Kwong and Edward K. B. Lee and L. B. Elman and L. F. McCluskey and Lubin Fang and Simone Feldengut and Albert Christian Ludolph and Virginia M-Y Lee and Heiko Braak and John Q. Trojanowski},
  journal={Annals of neurology},
  volume={74 1},
OBJECTIVE To see whether the distribution patterns of phosphorylated 43kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages. METHODS pTDP-43 immunohistochemistry was performed on 70 μm sections from ALS autopsy cases (N = 76) classified by clinical phenotype and genetic background. RESULTS ALS cases with the lowest burden of pTDP-43 pathology were characterized by lesions in the agranular motor… CONTINUE READING
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