Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity*

@inproceedings{Kumar2014StagesAC,
  title={Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity*},
  author={Satish Kumar and Katharina Tepper and Senthilvelrajan Kaniyappan and Jacek Biernat and Susanne Wegmann and Eckhard Mandelkow and Daniel J M{\"u}ller},
  booktitle={The Journal of biological chemistry},
  year={2014}
}
Several neurodegenerative diseases are characterized by the aggregation and posttranslational modifications of Tau protein. Its "repeat domain" (TauRD) is mainly responsible for the aggregation properties, and oligomeric forms are thought to dominate the toxic effects of Tau. Here we investigated the conformational transitions of this domain during oligomerization and aggregation in different states of β-propensity and pseudo-phosphorylation, using several complementary imaging and… CONTINUE READING
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