Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells.

@article{Ghule2008StagedAO,
  title={Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cells.},
  author={Prachi N Ghule and Zbigniew Dominski and Xiao-cui Yang and William Bill F Marzluff and Klaus A. Becker and J Wade Harper and Jane B Lian and Janet L Stein and Andre J van Wijnen and Gary S Stein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 44},
  pages={16964-9}
}
Human embryonic stem (hES) cells have an abbreviated G(1) phase of the cell cycle. How cells expedite G(1) events that are required for the initiation of S phase has not been resolved. One key regulatory pathway that controls G(1)/S-phase transition is the cyclin E/CDK2-dependent activation of the coactivator protein nuclear protein, ataxia-telangiectasia locus/histone nuclear factor-P (p220(NPAT)/HiNF-P) complex that induces histone gene transcription. In this study, we use the subnuclear… CONTINUE READING