Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells.


Stromal cells have been used to induce dopaminergic differentiation of mouse, primate, and human embryonic stem cells (hESCs), but the mechanism that governs this induction is unknown. In this manuscript, we show that medium conditioned by the stromal cell line PA6 (PA6-CM) can induce dopaminergic differentiation in neural stem cells (NSCs) derived from… (More)
DOI: 10.1089/scd.2009.0107