Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development
@article{Davis2013StageSR, title={Stage specific requirement of Gfr$\alpha$1 in the ureteric epithelium during kidney development}, author={Thomas Keefe Davis and Masato Hoshi and Sanjay Jain}, journal={Mechanisms of Development}, year={2013}, volume={130}, pages={506-518} }
28 Citations
To bud or not to bud: the RET perspective in CAKUT
- Medicine, BiologyPediatric Nephrology
- 2013
How RET signaling balances activating and inhibitory signals emanating from its docking tyrosines and its interaction with upstream and downstream regulators to precisely modulate different aspects of Wolffian duct patterning and branching morphogenesis is discussed.
HNF1B controls epithelial organization and cell polarity during ureteric bud branching and collecting duct morphogenesis
- BiologyDevelopment
- 2017
High-resolution analyses during ureteric bud branching reveal that HNFB1 is required for maintaining cell-cell contacts, for proper epithelial cell organization and for further differentiation of the collecting duct system in mouse.
Tumor-free elongation of mammalian nephrogenesis by excess fetal GDNF
- Medicine, BiologybioRxiv
- 2020
It is proposed that the lifespan of nephron progenitors is determined by mechanisms related to perception of GDNF and other signaling levels, which is capable of prolonging the nephrogenic program beyond its normal cessation without increasing the risk of kidney tumors.
Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF
- BiologyDevelopment
- 2021
It is shown that, despite its negative effects on kidney growth, genetic increase of GDNF prolongs the nephrogenic program beyond its normal cessation and suggests that sensing the signaling activity level is an important mechanism through which GDNF and other molecules contribute to nephron progenitor lifespan specification.
Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease
- Medicine, BiologyCurrent opinion in organ transplantation
- 2014
It is discussed how this intrinsic property of the ureteric bud might be exploited for engineering of kidney-like tissues potentially useful for the treatment of chronic kidney disease, acute kidney injury, and/or other renal diseases.
Regulation of Renal Differentiation by Trophic Factors
- Biology, MedicineFront. Physiol.
- 2018
How trophic factor-induced signaling contributes to the control of ureteric bud (UB) branching morphogenesis and to maintenance and differentiation of nephrogenic mesenchyme in embryonic kidney is discussed.
Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development
- BiologyDevelopment
- 2017
RNA-seq and in situ studies of progenitor pools driving the morphogenesis of mammalian kidney epithelial networks highlight gene sets linked to kidney and cross-organ branching programs.
Biallelic loss-of-function variants of GFRA1 cause lethal bilateral renal agenesis.
- Medicine, BiologyEuropean journal of medical genetics
- 2021
Regulation of Ureteric Bud Outgrowth and the Consequences of Disrupted Development
- Biology, Medicine
- 2016
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It is found that in the absence of the negative regulator Spry1, Gdnf, and Ret are no longer required for extensive kidney development, showing that the balance between positive signaling by RTKs and negative regulation of this signaling by SPRY1 is more critical than the specific role of GDNF.
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
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It is concluded that Wnt 11 and Ret/Gdnf cooperate in a positive autoregulatory feedback loop to coordinate ureteric branching by maintaining an appropriate balance of Wnt11-expressing ureTERic epithelium and Gdnf- expressing mesenchyme to ensure continued metanephric development.
GDNF/Ret signaling and the development of the kidney.
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GDNF does not provide the positional information required to specify the pattern of ureteric bud growth and branching, as its site of synthesis can be drastically altered with minimal effects on kidney development.
GFRα1 Expression in Cells Lacking RET Is Dispensable for Organogenesis and Nerve Regeneration
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The many faces of RET dysfunction in kidney
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A brief overview of the “many faces” of Ret dysfunction in kidney with particular emphasis on Ret’s signaling specificity and intergenic interactions that confer normal urinary system development is presented.
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Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.
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Role of fibroblast growth factor receptor signaling in kidney development.
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Fibroblast growth factor receptors (Fgfrs) consist of four signaling family members and one nonsignaling "decoy" receptor, Fgfr-like 1 (Fgfrl1), all of which are expressed in the developing kidney.…