Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation.

@article{Iyer2015StagespecificGA,
  title={Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation.},
  author={R. Padmavathi Iyer and Melissa Jo Caimano and Amit Luthra and David Axline and Arianna Corona and Dumitru Andrei Iacobas and Justin D. Radolf and I. Schwartz},
  journal={Molecular microbiology},
  year={2015},
  volume={95 3},
  pages={509-38}
}
Borrelia burgdorferi, the agent of Lyme disease, is maintained in nature within an enzootic cycle involving a mammalian reservoir and an Ixodes sp. tick vector. The transmission, survival and pathogenic potential of B. burgdorferi depend on the bacterium's ability to modulate its transcriptome as it transits between vector and reservoir host. Herein, we employed an amplification-microarray approach to define the B. burgdorferi transcriptomes in fed larvae, fed nymphs and in mammalian host… CONTINUE READING
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