Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu onPlasmodium falciparum

  title={Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu onPlasmodium falciparum},
  author={Nirbhay Kumar and Hong Zheng},
  journal={Parasitology Research},
Qinghaosu, an anti-malaria drug, has been found to kill not only asexual blood stages but also the early stages of gametocytes ofPlasmodium falciparum. The effect of qinghaosu in vitro depends on the concentration of the drug as well as on the initial parasitemia level (IC50=10–20 nM with 1% initial parasitemia). Resistance ofP. falciparum to other anti-malaria drugs, e.g., chloroquine and pyrimethamine, did not affect susceptibility of its asexual and sexual stages to qinghaosu… CONTINUE READING
Highly Cited
This paper has 122 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 57 extracted citations

Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives

International journal for parasitology. Drugs and drug resistance • 2015
View 1 Excerpt

122 Citations

Citations per Year
Semantic Scholar estimates that this publication has 122 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 27 references

Sensitivity of malaria

S Waki, Gu H-M, Zhu M-Y

Qinghaosu resistance in rodent malaria.

Transactions of the Royal Society of Tropical Medicine and Hygiene • 1986

Qinghaosuinduced changes in the morphology of Plasmodium inui

Jiang J-B, G Jacobs, Liang D-S, M Aikawa
Am J Trop Med Hyg • 1985

The chemotherapy of rodent malar

DC Warhurst