Stage-specific expression of Smad2 and Smad3 during folliculogenesis.

  title={Stage-specific expression of Smad2 and Smad3 during folliculogenesis.},
  author={Jian Xu and Jennifer I Oakley and E A Mcgee},
  journal={Biology of reproduction},
  volume={66 6},
Paracrine and autocrine growth factors can affect many different aspects of ovarian follicle development. Many members of the transforming growth factor beta (TGFbeta) family of growth factors and their receptors are expressed in developing follicles. However, the presence and function of the family of the TGFbeta signaling molecules known as Smads have not been evaluated during follicle development. We have demonstrated that two Smad family members that function as mediators for both activin… CONTINUE READING

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