Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta

@article{Macfarland1994StagespecificDO,
  title={Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta},
  author={Amrit Macfarland and David R. Abramovich and Stanley W. B. Ewen and Colin K. Pearson},
  journal={The Histochemical Journal},
  year={1994},
  volume={26},
  pages={417-423}
}
The distribution of P-glycoprotein in human placenta has been examined by immunohistochemistry using a battery of monoclonal antibodies (MRK-16, C219 and JSB-1). P-glycoprotein was located on the syncytiotrophoblast microvillus border in first-trimester placentas and some of the placental macrophages (Hofbauer cells) showed weak cytoplasmic staining. In term placentas, however, staining was not observed in the trophoblast but most of the Hofbauer cells displayed strong cytoplasmic staining. In… CONTINUE READING
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