Stage-specific differences in secretory profile of mesenchymal stromal cells (MSCs) subjected to early- vs late-stage OA synovial fluid.

@article{GmezAristizbal2017StagespecificDI,
  title={Stage-specific differences in secretory profile of mesenchymal stromal cells (MSCs) subjected to early- vs late-stage OA synovial fluid.},
  author={Alejandro G{\'o}mez-Aristiz{\'a}bal and Anirudh Sharma and M A Bakooshli and Mohit Kapoor and Penney M. Gilbert and Sowmya Viswanathan and R. Gandhi},
  journal={Osteoarthritis and cartilage},
  year={2017},
  volume={25 5},
  pages={737-741}
}
OBJECTIVE Although, mesenchymal stromal cells (MSCs) are being clinically investigated for their use in osteoarthritis (OA), it is unclear whether their postulated therapeutic properties are equally effective in the early- and late-stages of OA. In this study we investigated MSC cytokine secretion post-exposure to synovial fluid (SF), obtained from early- vs late-stage knee OA patients to justify a potential patient stratification strategy to maximize MSC-mediated treatment effects. METHOD… CONTINUE READING
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