Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development.

@article{Kim2002StagespecificAO,
  title={Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development.},
  author={Arianna Kim and Mohammad Athar and David R. Bickers and J -C. Gautier},
  journal={Photochemistry and photobiology},
  year={2002},
  volume={75 1},
  pages={58-67}
}
We have evaluated the in vivo correlation between the expression of cell cycle markers and skin tumor development in SKH-1 hairless mice in a complete photocarcinogenesis protocol. Irradiated mice developed an average of 16 tumors per animal by week 23 with the average number of carcinomas per mouse being 2.1. The expression of p53 and cyclins A and D1 was confined initially to sporadic single cells and gradually developed into foci of patchy intense staining in the basal and granular layers of… CONTINUE READING

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