Stage-specific adaptation of hypermutable Pseudomonas aeruginosa isolates during chronic pulmonary infection in patients with cystic fibrosis.

@article{Hogardt2007StagespecificAO,
  title={Stage-specific adaptation of hypermutable Pseudomonas aeruginosa isolates during chronic pulmonary infection in patients with cystic fibrosis.},
  author={Michael Hogardt and Christina Hoboth and Sabine Schmoldt and Christine Henke and Lutz Bader and J{\"u}rgen Heesemann},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 1},
  pages={
          70-80
        }
}
BACKGROUND Pseudomonas aeruginosa (PA) strains with defective DNA mismatch repair genes generate numerous bacterial variants because of high mutation rates. In cystic fibrosis (CF), such mutator strains may lead to the rapid selection of survivors that are specifically adapted to the hostile environment of the inflamed CF lung. METHODS Genotypes and phenotypes of 111 PA variants descending from 3 distinct mutator strains obtained from 3 patients with CF were systematically characterized… CONTINUE READING

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