Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.

@article{Fenton2006StageMC,
  title={Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.},
  author={Jenifer I Fenton and Norman G Hord},
  journal={Carcinogenesis},
  year={2006},
  volume={27 5},
  pages={893-902}
}
Clinical evidence reveals that the efficacy of dietary factors to prevent cancer is probably stage-dependent. The ability to demonstrate stage-specific effects of dietary compounds on normal, preneoplastic and malignant cell models may provide insights into puzzling clinical results from cancer chemoprevention trials. The relevance of these models to the field of cancer prevention is immense and will undoubtedly facilitate the ability to discover which dietary factors are most effective at… CONTINUE READING