Stage-dependent inhibition of Plasmodium falciparum by potent Ca2+ and calmodulin modulators.

@article{Tanabe1989StagedependentIO,
  title={Stage-dependent inhibition of Plasmodium falciparum by potent Ca2+ and calmodulin modulators.},
  author={K. Tanabe and A Izumo and Mitsutoshi Kato and Akihiro Miki and Syuichi Doi},
  journal={The Journal of protozoology},
  year={1989},
  volume={36 2},
  pages={139-43}
}
The effects of Ca2+ channel blockers, verapamil, nicardipine and diltiazem, and of potent calmodulin (CaM) inhibitors, trifluoperazine (TFP), calmidazolium, W-7 and W-5, on Plasmodium falciparum in culture were examined. Among Ca2+ blockers, nicardipine was the most potent with the 50% inhibitory concentration (IC50) of 4.3 microM at 72 h after culture. Parasites were more sensitive to calmidazolium and W-7 with IC50 of 3.4 and 4.5 microM, respectively, than to TFP and W-5. All Ca2+ blockers… CONTINUE READING
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…