Stage and cell-specific expression of the adenosine 3',5' monophosphate-phosphodiesterase genes in the rat seminiferous epithelium.

@article{Morena1995StageAC,
  title={Stage and cell-specific expression of the adenosine 3',5' monophosphate-phosphodiesterase genes in the rat seminiferous epithelium.},
  author={Anna Rita Morena and Carla Boitani and S de Grossi and Mario Stefanini and M. P{\'e}rez-D{\'i}az Conti},
  journal={Endocrinology},
  year={1995},
  volume={136 2},
  pages={687-95}
}
Four genes (ratPDE1/IVc, ratPDE2/IVa, ratPDE3/IVd, and ratPDE4/IVb) encoding different isoforms of phosphodiesterase that specifically hydrolyze the second messenger cAMP (cAMP-PDEs) are present in the rat. Previous data from our laboratory indicated that these genes are differentially expressed in the somatic and germ cells of the seminiferous epithelium of the testis. To further characterize their spatial and temporal expression in the seminiferous tubules, in situ hybridization was used to… CONTINUE READING

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