Stage-Specific miRs in Chondrocyte Maturation: Differentiation-Dependent and Hypertrophy-Related miR Clusters and the miR-181 Family.

@article{Gabler2015StageSpecificMI,
  title={Stage-Specific miRs in Chondrocyte Maturation: Differentiation-Dependent and Hypertrophy-Related miR Clusters and the miR-181 Family.},
  author={Jessica Gabler and Martin Ruetze and Katharina L. Kynast and Tobias Grossner and Solvig Diederichs and Wiltrud Richter},
  journal={Tissue engineering. Part A},
  year={2015},
  volume={21 23-24},
  pages={2840-51}
}
Human mesenchymal stromal cells (hMSC) differentiating toward the chondrogenic lineage recapitulate successive phases of embryonic chondrocyte maturation developing from progenitor cells to hypertrophic chondrocytes. Osteoarthritic cartilage is characterized by an alteration in chondrocyte metabolism and upregulation of hypertrophic differentiation markers. A number of studies point toward a functional role for microRNAs (miRs) in controlling chondrocyte differentiation and development of… CONTINUE READING
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