Stage-Specific Expression of Two Neighboring Crlz1 and IgJ Genes during B Cell Development Is Regulated by Their Chromatin Accessibility and Histone Acetylation1

@article{Lim2006StageSpecificEO,
  title={Stage-Specific Expression of Two Neighboring Crlz1 and IgJ Genes during B Cell Development Is Regulated by Their Chromatin Accessibility and Histone Acetylation1},
  author={Jung-Hyun Lim and Sun-Jung Cho and Sung-Kyun Park and Jiyoung Kim and D. Cho and W. Lee and C. Kang},
  journal={The Journal of Immunology},
  year={2006},
  volume={177},
  pages={5420 - 5429}
}
The IgJ gene is expressed in the plasma cell stage. However, its neighboring charged amino acid-rich leucine zipper 1 (Crlz1) gene, which is mapped 30 kb upstream of the IgJ gene in mice, is shown to be expressed in the pre-B cell stage. These stage-specific expressions of two neighboring genes are found to be regulated by their chromatin accessibility and acetylation. Hypersensitive site 1 on the IgJ promoter is opened in the plasma cells, whereas hypersensitive sites 9/10 on the Crlz1… Expand
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