Stage I Non-small Cell Lung Cancer (NSCLC) in Patients Aged 75 Years and Older: Does Age Determine Survival After Radical Treatment?

@article{Palma2010StageIN,
  title={Stage I Non-small Cell Lung Cancer (NSCLC) in Patients Aged 75 Years and Older: Does Age Determine Survival After Radical Treatment?},
  author={David A. Palma and Scott Tyldesley and Finbarr Sheehan and Islam G. Mohamed and Sally L. Smith and Elaine S. Wai and Nevin Murray and Suresh Senan},
  journal={Journal of Thoracic Oncology},
  year={2010},
  volume={5},
  pages={818-824}
}
Introduction: Curative treatment of stage I non-small cell lung cancer (NSCLC) in elderly patients represents a therapeutic challenge. Data examining outcomes for the elderly after radical radiotherapy (RT) or surgery in the same geographic population are limited. Methods: Using prospective databases from British Columbia, patients with stage I NSCLC treated curatively with either surgery or RT between 2000 and 2006 were identified. Kaplan-Meier, Cox regression, and competing risk analyses were… 
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TLDR
Elderly patients with resectable NSCLC according to stage are frequently excluded from surgery due to comorbid conditions, and their favourable 30-day and long-term survival indicate that more elderly patients with NSCLc could be operated on.
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TLDR
The role of surgery or other alternative therapies, in patients with advanced stages, extensive nodal involvement and/or requiring extensive surgical resection for curative intent, is still unclear and further studies are certainly needed.
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TLDR
It is suggested that segmentectomy should be the preferred technique for limited resection of patients with stage IA NSCLC, based on the patient’s preoperative characteristics.
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TLDR
Although operation for NSCLC in the elderly patients causes more complications, especially in the cardiopulmonary system, their outcome showed better than their younger counterparts, and Pulmonary resection for elderly patients may get longer disease control.
Preoperative quality of life predicts survival following pulmonary resection in stage I non-small-cell lung cancer.
  • C. Pompili, M. Salati, +4 authors A. Brunelli
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2013
TLDR
The physical component of QoL was associated with overall and cancer-specific survivals in patients operated on for early-stage NSCLC and supportive interventions aimed at improving the perception of physical well-being should be tested to verify whether they can improve long-term prognosis after lung cancer surgery.
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    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2011
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