Stage- and region-dependent responses of chick wing-bud mesenchymal cells to retinoic acid in serum-free microcultures.


Retinoic acid (RA) has been shown to affect skeletal patterning in vivo in both developing and regenerating limbs. Regional differences in RA concentrations alone cannot account for the region-specific cell behaviors involved in limb-skeletal morphogenesis. The present study explores a role for regional differences in signal interpretation in RA's effects… (More)