Stachydrine Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Suppressing Autophagy.

@article{Cao2017StachydrinePA,
  title={Stachydrine Protects Against Pressure Overload-Induced Cardiac Hypertrophy by Suppressing Autophagy.},
  author={Tong-Tong Cao and Hui-hua Chen and Zhiwei Dong and Yan-Wu Xu and P Zhao and Wei Guo and Hong-Chang Wei and Chen Zhang and Rong Lu},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2017},
  volume={42 1},
  pages={103-114}
}
BACKGROUND Autophagy is required for the maintenance of cardiomyocyte homeostasis. However, excessive autophagy plays a maladaptive role in pressure overload-induced heart failure. To identify mechanisms by which Stachydrine inhibits pressure overload-induced cardiac hypertrophy, we determined inhibitory activities against activation of NADPH oxidase, reactive oxygen species(ROS) production and excessive activation of autophagy. METHODS Stachydrine was administered intragastrically to Wistar… CONTINUE READING

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( 3 rd edition )

  • BL Prosser, CW Ward, WJ Lederer
  • 2016

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