Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D.

@article{Brown1997StableTO,
  title={Stable transfection of U937 cells with sense or antisense RXR-alpha cDNA suggests a role for RXR-alpha in the control of monoblastic differentiation induced by retinoic acid and vitamin D.},
  author={Timothy Emmanuel Brown and Thomas Robert Stonehouse and Joel W. Branch and Paul M. Brickell and David R. Katz},
  journal={Experimental cell research},
  year={1997},
  volume={236 1},
  pages={
          94-102
        }
}
Although retinoic acid (RA) has been known for many years to be a modulating agent that plays a role in generating both granulocytes and monocytes, the molecular mechanism underlying this role has not been defined in the monoblast lineage. In particular, the part played by the retinoid X receptors (RXRs), which are members of the steroid/thyroid hormone nuclear receptor family, has not been explored. In this study, therefore, the human monoblastic leukemia cell line U937 has been used as a… CONTINUE READING
BETA

Similar Papers

Loading similar papers…