Stable size distribution of amyloid plaques over the course of Alzheimer disease.

Abstract

Amyloid β plaques are a key pathologic feature of Alzheimer disease (AD), but whether plaque sizes increase or stabilize over the course of AD is unknown. We measured the size distribution of total immunoreactive (10D5-positive) and dense-core (Thioflavin S-positive) plaques in the temporal neocortex of a large group of subjects with AD and age-matched… (More)
DOI: 10.1097/NEN.0b013e31825e77de

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