Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector

Abstract

Limb-girdle muscular dystrophies 2C–F represent a family of autosomal recessive diseases caused by defects in sarcoglycan genes. The cardiomyopathic hamster is a naturally occurring model for limb-girdle muscular dystrophy caused by a primary deficiency in δ-sarcoglycan. We show here that acute sarcolemmal disruption occurs in this animal model during… (More)
DOI: 10.1038/7439

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