Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant

@article{Weimann2003StableRH,
  title={Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant},
  author={James M. Weimann and Clas B. Johansson and Angelica Trejo and Helen M. Blau},
  journal={Nature Cell Biology},
  year={2003},
  volume={5},
  pages={959-966}
}
Heterokaryons are the product of cell fusion without subsequent nuclear or chromosome loss. Decades of research using Sendai-virus or polyethylene glycol (PEG)-mediated fusion in tissue culture showed that the terminally differentiated state of a cell could be altered. But whether stable non-dividing heterokaryons could occur in animals has remained unclear. Here, we show that green fluorescent protein (GFP)-positive bone-marrow-derived cells (BMDCs) contribute to adult mouse Purkinje neurons… CONTINUE READING
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Chromosomal variation in neurons of the developing and adult mammalian nervous system.

Proceedings of the National Academy of Sciences of the United States of America • 2001

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