Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts.

@article{Veillard2014StableMA,
  title={Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts.},
  author={Anne-Cl{\'e}mence Veillard and Hendrik Marks and Andreia S Bernardo and Luc Jouneau and Denis Lalo{\"e} and Laurent Boulanger and Anita M. Kaan and Vincent Brochard and Matteo Tosolini and Roger Pedersen and Henk Stunnenberg and Alice Jouneau},
  journal={Stem cells and development},
  year={2014},
  volume={23 17},
  pages={2014-29}
}
Embryonic Stem Cells (ESCs) and Epiblast Stem Cells (EpiSCs) are the in vitro representatives of naïve and primed pluripotency, respectively. It is currently unclear how their epigenomes underpin the phenotypic and molecular characteristics of these distinct pluripotent states. Here, we performed a genome-wide comparison of DNA methylation between ESCs and EpiSCs by MethylCap-Seq. We observe that promoters are preferential targets for methylation in EpiSC compared to ESCs, in particular high… CONTINUE READING

From This Paper

Topics from this paper.
13 Citations
65 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Similar Papers

Loading similar papers…