Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions

@article{Fan2010StableIM,
  title={Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions},
  author={Teresa W.-M. Fan and Peixiong Yuan and Andrew N. Lane and Richard M. Higashi and Yun Wang and Anahita B. Hamidi and Rulun Zhou and Xavier Vidal Guitart and Guang Chen and Husseini K. Manji and Rima Kaddurah-Daouk},
  journal={Metabolomics},
  year={2010},
  volume={6},
  pages={165-179}
}
Despite the long-established therapeutic efficacy of lithium in the treatment of bipolar disorder (BPD), its molecular mechanism of action remains elusive. Newly developed stable isotope-resolved metabolomics (SIRM) is a powerful approach that can be used to elucidate systematically how lithium impacts glial and neuronal metabolic pathways and activities, leading ultimately to deciphering its molecular mechanism of action. The effect of lithium on the metabolism of three different 13C-labeled… CONTINUE READING

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