Stable isotope labeling by amino acids in cell culture (SILAC).

  title={Stable isotope labeling by amino acids in cell culture (SILAC).},
  author={S Gruhler and Irina Kratchmarova},
  journal={Methods in molecular biology},
Quantitative proteomics has become a pivotal tool that has been applied to the investigation of many different biological processes such diverse as the detection of biomarkers in tissue samples, the regulation of cell signaling, and the characterization of protein interactions. Stable isotope labeling techniques have facilitated the precise quantitation of changes in protein abundance by mass spectrometry. Among different choices, Stable Isotope Labeling by Amino acids in Cell culture (SILAC… CONTINUE READING
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