Stable isotope dilution analysis of succinylacetone using electron capture negative ion mass fragmentography: an accurate approach to the pre- and neonatal diagnosis of hereditary tyrosinemia type I.

Abstract

A sensitive and accurate isotope dilution assay using electron capture negative ion mass fragmentography was developed for succinylacetone in amniotic fluid, plasma and urine. The method utilizes (D4)-5(3)-methyl-3(5)-isoxasole propionic acid as internal standard. Sample pretreatment consisted of oximation at pH less than 2 to 5(3)-methyl-3(5)-isoxasole… (More)

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Cite this paper

@article{Jakobs1988StableID, title={Stable isotope dilution analysis of succinylacetone using electron capture negative ion mass fragmentography: an accurate approach to the pre- and neonatal diagnosis of hereditary tyrosinemia type I.}, author={Cornelius Jakobs and Lambertus Dorland and B Wikkerink and Robert Martin Kok and Antonius P de Jong and Sybe K. Wadman}, journal={Clinica chimica acta; international journal of clinical chemistry}, year={1988}, volume={171 2-3}, pages={223-31} }