Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

@article{Kim2015StableIA,
  title={Stable inhibitory activity of regulatory T cells requires the transcription factor Helios},
  author={Hye-Jung Kim and R. Anthony Barnitz and Taras Kreslavsky and Flavian D. Brown and H F Moffett and Madeleine E Lemieux and Yasemin Kaygusuz and Torsten B. Meissner and Tobias A. W. Holderried and Susan Chan and Philippe Kastner and W Nicholas Haining and Harvey Cantor},
  journal={Science},
  year={2015},
  volume={350},
  pages={334-339}
}
The maintenance of immune homeostasis requires regulatory T cells (Tregs). Given their intrinsic self-reactivity, Tregs must stably maintain a suppressive phenotype to avoid autoimmunity. We report that impaired expression of the transcription factor (TF) Helios by FoxP3+ CD4 and Qa-1–restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice. Helios-deficient Tregs develop an unstable phenotype during inflammatory responses characterized by reduced FoxP3 expression… CONTINUE READING

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