Stable growth of wild-type hepatitis A virus in cell culture.

  title={Stable growth of wild-type hepatitis A virus in cell culture.},
  author={Krishnamurthy Konduru and Gerardo G. Kaplan},
  journal={Journal of virology},
  volume={80 3},
Human wild-type (wt) hepatitis A virus (HAV), the causative agent of acute hepatitis, barely grows in cell culture and in the process accumulates attenuating and cell culture-adapting mutations. This genetic instability of wt HAV in cell culture is a major roadblock to studying HAV pathogenesis and producing live vaccines that are not overly attenuated for humans. To develop a robust cell culture system capable of supporting the efficient growth of wt HAV, we transfected different cell lines… CONTINUE READING


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