Corpus ID: 8231925

Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.

@article{Kliek2013StableGP,
  title={Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.},
  author={Robert Kli{\vc}ek and Danijela Kolenc and Jelena mentor {\vS}uran and Domagoj Drmic and Luka Br{\vc}i{\'c} and Gorana Aralica and Marko Sever and Jadranka Katan{\vc}i{\'c} Holjevac and Bo{\vz}o Radi{\'c} and Tatjana Paveli{\'c} Turudi{\'c} and Antonio Kokot and Leonardo Patrlj and Rudolf Ru{\vc}man and Sven Seiwerth and Predrag Sikiric},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2013},
  volume={64 5},
  pages={
          597-612
        }
}
  • R. Kliček, D. Kolenc, +12 authors P. Sikiric
  • Published 2013
  • Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Stable gastric pentadecapeptide BPC 157 was suggested to link inflammatory bowel disease and multiple sclerosis, and thereby, shown to equally counteract the models of both of those diseases. [...] Key Method For colitis, cysteamine (400 mg/kg intrarectally (1 ml/rat)) and colon-colon anastomosis (sacrifice at day 3, 5, 7, and 14) were used.Expand
Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula.
TLDR
BPC 157 effects appear to be suited to inducing full healing of colocutaneous fistulas in rats, with both colon and vesical defects simultaneously ameliorated and eventually healed. Expand
Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats.
TLDR
Regularly, rectovaginal fistulas exhibited poor healing, with both of the defects persisting, continuous fistula leakage, defecation through the fistula, advanced adhesion formation and intestinal obstruction, but BPC 157 given perorally or intraperitoneally, in μg- and ng-regimens rapidly improved the whole presentation. Expand
Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats
TLDR
BPC 157 therapy’s beneficial effects resulted in healing and no stone formation, with µg- and ng-regimens, either given daily perorally in drinking water or intraperitoneally. Expand
Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats
TLDR
The functional rescue provided by BPC 157 after spinal cord injury implies that B PC 157 therapy can impact all stages of the secondary injury phase. Expand
Bowel adhesion and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine in rats
TLDR
BPC 157 therapy can be suited for the realization of the peritoneal defect healing with minimal or no adhesion formation and unlike diverse effect of the NO-agents, the BPC 157 application effect regularly combines decrease on the increased NO- and MDA- values and the beneficial outcome (less adhesion Formation). Expand
Effects of Diclofenac, L-NAME, L-Arginine, and Pentadecapeptide BPC 157 on Gastrointestinal, Liver, and Brain Lesions, Failed Anastomosis, and Intestinal Adaptation Deterioration in 24 Hour-Short-Bowel Rats
TLDR
Diclofenac combined with nitric oxide (NO) system blockade was used to resolve the increasing early risks following major massive small bowel resectioning surgery, suggesting therapy with BPC 157 and the Nitric oxide synthase (NOS substrate) L-arginine, is efficacious. Expand
Učinak pentadekapeptida BPC 157 na cijeljenje rektovaginalnih fistula u štakora [The effect of pentadecapeptide BPC 157 on healing of rectovaginal fistulas in rats]
TLDR
BPC 157 effects appear to be suited to induce a full healing of rectovaginal fistulas in rats, with both rectal and vaginal defects simultaneously ameliorated and eventually healed. Expand
Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights
TLDR
BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals and involves the NO system. Expand
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
TLDR
The antiulcer peptide, stable gastric pentadecapeptide BPC 157 is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing. Expand
Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME
TLDR
Innate NO-system disability for esophagogastric anastomoses, including L-NAME-worsening, suggests that these effects could be corrected by L-arginine and almost completely eliminated by BPC 157 therapy. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 85 REFERENCES
Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats
TLDR
Rats treated with pentadecapeptide BPC 157 showed not different jejunal and ileal diameters, constant jejunum-to-ileum ratio, and increased anastomosis breaking strength, suggesting it could be helpful to cure short bowel syndrome. Expand
Pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system.
TLDR
BPC 157 accelerated parenterally or perorally the healing of colonic and skin defect, leading to the suitable closure of the fistula, macro/microscopically, biomechanically, and functionally (larger water volume sustained without fistula leaking). Expand
Salutary effect of gastric pentadecapeptide BPC 157 in two different stress urinary incontinence models in female rats
TLDR
Pentadecapeptide BPC 157, applied parenterally or per-orally, appears to ameliorate the SUI in rat models, improving the otherwise detrimental course of healing after VD and TU, which may be analogous to human injury. Expand
Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat
TLDR
This study showed BPC 157 to have a beneficial effect on ileoileal anastomosis healing in the rat, and induces markedly higher volume and pressure values, with a continuous increase toward healthy values. Expand
Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats
TLDR
In the adjuvant arthritis studies, the lesion's development seems to be considerably reduced after single pentadecapeptide medication, and even more attenuated in rats daily treated with BPC 157, likely pointing to a special anti-inflammatory and mucosal integrity protective effect. Expand
The stable gastric pentadecapeptide BPC 157, given locally, improves CO2 laser healing in mice.
TLDR
BPC 157 consistently improved healing after the CO(2) laser injury, both macroscopically and microscopically. Expand
Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract.
TLDR
In rat esophagitis and failed function of both lower esophageal sphincter (LES) and pyloricSphincters (PS), BPC 157 increased pressure in both spHincters till normal and reduced esophAGitis, and may improve gastrointestinal tract therapy. Expand
Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: diclofenac-induced gastrointestinal, liver, and encephalopathy lesions.
TLDR
The very extensive antagonization of diclofenac toxicity achieved with BPC 157 (μg-/ng-regimen, intraperitoneally, per-orally) may encourage its further use as a therapy to counteract dicL ofenac- and other NSAID-induced toxicity. Expand
Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat
TLDR
It is suggested BPC 157 improved healing of acute ligament injuries in further ligament therapy with consistent functional, biomechanical, macroscopic and histological healing improvements. Expand
Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat
TLDR
BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function. Expand
...
1
2
3
4
5
...