Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.

@article{Hadingham1992StableEO,
  title={Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.},
  author={Karen L Hadingham and Patricia C Harkness and Ruth M Mckernan and Kathleen Quirk and B{\'e}atrice Le Bourdell{\`e}s and Andrea Horne and John A. Kemp and Eric A. Barnard and Colman Ragan and Paul John Whiting},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 14},
  pages={6378-82}
}
The differential sensitivity of type A gamma-aminobutyric acid (GABAA) receptors to benzodiazepine ligands seen in the mammalian nervous system is thought to be generated by the existence of a number of different receptor subtypes, assembled from a range of closely related subunits (alpha 1-6, beta 1-3, gamma 1-3, and delta) encoded by discrete genes. The characteristics of a given subtype can be determined by the coexpression of cloned cDNAs encoding the subunits of interest. Two transient… CONTINUE READING

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