Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains.

@article{Strugnell1990StableEO,
  title={Stable expression of foreign antigens from the chromosome of Salmonella typhimurium vaccine strains.},
  author={Richard A. Strugnell and Duncan J Maskell and Neil T Fairweather and Derek Pickard and Aston Cockayne and Casey L Penn and Gordon Dougan},
  journal={Gene},
  year={1990},
  volume={88 1},
  pages={57-63}
}
A simple and versatile system has been developed using a new cloning vector which can serve as a vehicle for integrating DNA fragments, which direct the expression of heterologous antigens, into the aroC gene on the Salmonella chromosome. The system is based on Escherichia coli plasmid vectors which contain the DNA fragment, cloned from the chromosome of S… CONTINUE READING