Stable expression of a neuronal gamma-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence.

@article{Clark1994StableEO,
  title={Stable expression of a neuronal gamma-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence.},
  author={John David Clark and Susan Gaye Amara},
  journal={Molecular pharmacology},
  year={1994},
  volume={46 3},
  pages={550-7}
}
The transport proteins that mediate gamma-aminobutyric acid (GABA) reuptake have been major targets for the development of agents to treat neurological diseases such as epilepsy, where augmentation of GABAergic function is indicated. The recent isolation of cDNAs for four distinct brain GABA carriers has provided an avenue for creating more specific and selective antagonists of GABA transport. An LLC-PK1 cell line stably expressing GABA transporter type 3 (GAT-3), a beta-alanine-sensitive… CONTINUE READING