Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice.

@article{Domann1994StableEO,
  title={Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice.},
  author={F E Domann and John P. Levy and Michael J. Birrer and G. Timothy Bowden},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1994},
  volume={5 1},
  pages={
          9-16
        }
}
We have stably expressed a trans-activation suppressing deletion mutant of the human c-jun gene (TAM-67) in the malignant mouse epidermal cell lines 10Gy5 and PDV. Expression of the p26 mJUN protein blocked both constitutive and inducible transcriptional trans-activation of several AP-1 responsive reporter chloramphenicol acetyltransferase constructs. p26 mJUN was able to block both 12-O-tetradecanoylphorbol-13-acetate (TPA) and okadaic acid induced expression of the mouse stromelysin gene in… CONTINUE READING
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