Stable deuterium internal standard for the isotope-dilution LC-MS/MS analysis of elastin degradation.

@article{Ma2013StableDI,
  title={Stable deuterium internal standard for the isotope-dilution LC-MS/MS analysis of elastin degradation.},
  author={Shuren Ma and Gerard M. Turino and Takahiro Hayashi and Hiroto Yanuma and Toyonobu Usuki and Yong Yoo Lin},
  journal={Analytical biochemistry},
  year={2013},
  volume={440 2},
  pages={158-65}
}
Chemical synthesis of the deuterium isotope desmosine-d4 has been achieved. This isotopic compound possesses all four deuterium atoms at the alkanyl carbons of the alkyl amino acid substitution in the desmosine molecule and is stable toward acid hydrolysis; this is required in the measurement of two crosslinking molecules, desmosine and isodesmosine, as… CONTINUE READING