Stable chromosomal units determine the spatial and temporal organization of DNA replication.

@article{Sadoni2004StableCU,
  title={Stable chromosomal units determine the spatial and temporal organization of DNA replication.},
  author={Nicolas Sadoni and M. C. Cardoso and Ernst H. Stelzer and Heinrich Leonhardt and Daniele Zink},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 22},
  pages={5353-65}
}
DNA replication occurs in mammalian cells at so-called replication foci occupying defined nuclear sites at specific times during S phase. It is an unresolved problem how this specific spatiotemporal organization of replication foci is determined. Another unresolved question remains as to what extent DNA is redistributed during S phase. To investigate these problems, we visualized the replicating DNA and the replication machinery simultaneously in living HeLa cells. Time-lapse analyses revealed… CONTINUE READING
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