Stable chromosomal units determine the spatial and temporal organization of DNA replication

@article{Sadoni2004StableCU,
  title={Stable chromosomal units determine the spatial and temporal organization of DNA replication},
  author={Nicolas Sadoni and M. C. Cardoso and E. Stelzer and H. Leonhardt and D. Zink},
  journal={Journal of Cell Science},
  year={2004},
  volume={117},
  pages={5353 - 5365}
}
  • Nicolas Sadoni, M. C. Cardoso, +2 authors D. Zink
  • Published 2004
  • Biology, Medicine
  • Journal of Cell Science
  • DNA replication occurs in mammalian cells at so-called replication foci occupying defined nuclear sites at specific times during S phase. It is an unresolved problem how this specific spatiotemporal organization of replication foci is determined. Another unresolved question remains as to what extent DNA is redistributed during S phase. To investigate these problems, we visualized the replicating DNA and the replication machinery simultaneously in living HeLa cells. Time-lapse analyses revealed… CONTINUE READING

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