Stable binding of the eukaryotic acidic phosphoproteins to the ribosome is not an absolute requirement for in vivo protein synthesis.

@article{Remacha1992StableBO,
  title={Stable binding of the eukaryotic acidic phosphoproteins to the ribosome is not an absolute requirement for in vivo protein synthesis.},
  author={Miguel Remacha and C. S. dos Santos and Bego{\~n}ia Bermejo and T Naranda and Juan P. G. Ballesta},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 17},
  pages={12061-7}
}
The genes encoding the four acidic ribosomal phosphoproteins have been inactivated in Saccharomyces cerevisae by recombination with truncated genes carrying different genetic markers. By crossing single haploid disruptants, strains harboring two simultaneously inactivated acidic protein genes were constructed. None of the six possible double disruptions was lethal, but the simultaneous inactivation of either YP1 alpha and YP1 beta(L44') or YP2 alpha(L44) and YP2 beta(L45) caused an important… CONTINUE READING

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