Stable attachment for herpes simplex virus penetration into human cells requires glycoprotein D in the virion and cell receptors that are missing for entry-defective porcine cells.

@article{Prez1998StableAF,
  title={Stable attachment for herpes simplex virus penetration into human cells requires glycoprotein D in the virion and cell receptors that are missing for entry-defective porcine cells.},
  author={Aleida P{\'e}rez and A. Oveta Fuller},
  journal={Virus research},
  year={1998},
  volume={58 1-2},
  pages={21-34}
}
Clonal porcine kidney cell lines that are non-permissive for herpes simplex virus (HSV) infection produced five orders of magnitude less virus than human cells, contained heparan sulfate (HS), and are restricted only at HSV entry. By fluorescent activated cell sorting, we examined HSV attachments to porcine and human cells. Stable attachment to susceptible human embryonic lung (HEL) cells occurred with infectious wild-type virus, complemented gD or gH mutant viruses, or non-infectious virus… CONTINUE READING