Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptor-related protein and promotes urokinase accumulation in the medium of an astrocytic tumor cell line.

@article{Hussaini1999StableAR,
  title={Stable antisense RNA expression neutralizes the activity of low-density lipoprotein receptor-related protein and promotes urokinase accumulation in the medium of an astrocytic tumor cell line.},
  author={Isa Marte Hussaini and Melandee D Brown and Amanda M Weaver and John Carpenter and Larry R. Karns and Scott VandenBerg and Steven L Gonias},
  journal={Antisense & nucleic acid drug development},
  year={1999},
  volume={9 2},
  pages={
          183-90
        }
}
Low-density lipoprotein receptor-related protein (LRP) binds and internalizes multiple ligands that are structurally and functionally diverse. However, the effects of LRP on cellular phenotype remain unclear. To study LRP in human astrocytic tumor cells, we designed LRP antisense RNA expression constructs in which the antisense cDNA fragment was expressed under the control of the cytomegalovirus (CMV) promoter. U-1242 MG astrocytic tumor cells were transfected with the antisense constructs and… CONTINUE READING
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