• DOI:10.1021/LA053158B
• Corpus ID: 31332670

Stable and pH-sensitive nanogels prepared by self-assembly of chitosan and ovalbumin.

@article{Yu2006StableAP,
  title={Stable and pH-sensitive nanogels prepared by self-assembly of chitosan and ovalbumin.},
  author={Shaoyong Yu and Jinhua Hu and Xiaoyun Pan and Ping Yao and Ming Jiang},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2006},
  volume={22 6},
  pages={
          2754-9
        }
}

• Shaoyong Yu, Jinhua Hu, +2 authors Ming Jiang
• Published 16 February 2006
• Materials Science, Biology, Engineering
• Langmuir : the ACS journal of surfaces and colloids

Two natural macromolecules, chitosan and ovalbumin, were used to produce nanogels by a new, green, and convenient method. Chitosan and ovalbumin solutions were mixed; the pH of the resulting solution was adjusted; and the solution was successively stirred and heated. After that, ovalbumin gelled forming nanospheres. The chitosan chains are supposed to be partly trapped in the nanogel core upon heating because of the electrostatic attractions between chitosan and ovalbumin, while the rest of the chitosan chains should form the shell of the nanogels. The nanogels did not change the size distribution after long-time storage and did not dissociate in the pH range of 2-10.5. The dispersibility, size, and hydrophobicity/hydrophilicity of the nanogels are pH-dependent. The nanogels are good candidates for cosmetic and pharmaceutical applications.