Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide

@article{Alexeev1998StableAI,
  title={Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide},
  author={Vitali Alexeev and Kyonggeun Yoon},
  journal={Nature Biotechnology},
  year={1998},
  volume={16},
  pages={1343-1346}
}
Experimental strategies have been developed to correct point mutations using chimeric oligonucleotides composed of RNA and DNA. We used these RNA-DNA oligonucleotides to correct a point mutation in mouse tyrosinase, a key enzyme for melanin synthesis and pigmentation. Melanocytes derived from albino mice contain a homozygous point mutation (TGT→TCT) in the tyrosinase gene, resulting in an amino acid change from Cys→Ser. Correction of this point mutation results in the restoration of tyrosinase… CONTINUE READING

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