Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones.

Abstract

α-Synuclein aggregation and accumulation in Lewy bodies are implicated in progressive loss of dopaminergic neurons in Parkinson disease and related disorders. In neurons, the Hsp70s and their Hsp40-like J-domain co-chaperones are the only known components of chaperone network that can use ATP to convert cytotoxic protein aggregates into harmless natively… (More)
DOI: 10.1074/jbc.M110.127753

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@article{Hinault2010StableAO, title={Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones.}, author={M P Hinault and America Farina Henriquez Cuendet and Rayees U. H. Mattoo and Mounir Mensi and Giovanni Dietler and Hilal A Lashuel and Pierre Goloubinoff}, journal={The Journal of biological chemistry}, year={2010}, volume={285 49}, pages={38173-82} }