Stable activation of single Ca2+ release-activated Ca2+ channels in divalent cation-free solutions.

@article{Braun2001StableAO,
  title={Stable activation of single Ca2+ release-activated Ca2+ channels in divalent cation-free solutions.},
  author={F J Braun and Lisa M. Broad and David Lee Armstrong and James W Putney},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 2},
  pages={1063-70}
}
The regulation of store-operated, calcium-selective channels in the plasma membrane of rat basophilic leukemia cells (RBL-2H3 m1), an immortalized mucosal mast cell line, was studied at the single-channel level with the patch clamp technique by removing divalent cations from both sides of the membrane. The activity of the single channels in excised patches could be modulated by Ca(2+), Mg(2+), and pH. The maximal activation of these channels by divalent cation-free conditions occurred… CONTINUE READING

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