Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control.

@article{Fabre2005StableAO,
  title={Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control.},
  author={St{\'e}phanie Fabre and Val{\'e}rie Lang and Julie Harriague and Aude Jobart and Terry G. Unterman and Alain Trautmann and Georges Bismuth},
  journal={Journal of immunology},
  year={2005},
  volume={174 7},
  pages={4161-71}
}
We have previously reported at the single cell level that PI3K is activated after conjugate formation between T lymphocytes and APCs. However, in contrast to cells exposed to an asymmetrical signal that usually increase 3'-phosphoinositides (3'-PI) transiently in the region of the activated receptors, T cells contacting APC accumulate 3'-PI across their whole plasma membrane far beyond the region of the immunological synapse (IS). Importantly, this effect is maintained over time, for hours, and… CONTINUE READING

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