Stable accumulation of p67phox at the phagosomal membrane and ROS production within the phagosome.

Abstract

Production of ROS by the leukocyte NADPH oxidase is essential for the destruction of pathogenic bacteria inside phagosomes. The enzyme is a complex of cytosolic and membranous subunits that need to assemble upon activation. Biochemical data suggest that the complex is renewed continuously during activity. Furthermore, it is generally assumed that complex… (More)
DOI: 10.1189/jlb.1210701

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