Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

@inproceedings{Ciabrelli2017StablePT,
  title={Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila},
  author={Filippo Ciabrelli and Federico Comoglio and S Fellous and Boyan Bonev and Maria Ninova and Quentin Szabo and Anne Xuereb and Christophe Klopp and A. A. Aravin and Renato Paro and Fr{\'e}d{\'e}ric Bantignies and Giacomo Cavalli},
  booktitle={Nature Genetics},
  year={2017}
}
Transgenerational epigenetic inheritance (TEI) describes the transmission of alternative functional states through multiple generations in the presence of the same genomic DNA sequence. Very little is known about the principles and the molecular mechanisms governing this type of inheritance. Here, by transiently enhancing 3D chromatin interactions, we established stable and isogenic Drosophila epilines that carry alternative epialleles, as defined by differential levels of Polycomb-dependent… CONTINUE READING
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