Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates

Abstract

The role of hyperphosphorylation of the microtubule-associated protein tau in the pathological processes of several neurodegenerative diseases is becoming better understood. Consequently, development of new compounds capable of preventing tau hyperphosphorylation is an increasingly hot topic. For this reason, dependable in vitro and in vivo models that… (More)
DOI: 10.1007/s12031-012-9716-6

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Cite this paper

@inproceedings{Lffler2012StableMT, title={Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer’s Disease Drug Candidates}, author={Tina L{\"{o}ffler and Stefanie Flunkert and Nicole Taub and Emma L. Schofield and Malcolm Ward and Manfred Windisch and Birgit Hutter-Paier}, booktitle={Journal of Molecular Neuroscience}, year={2012} }