Stable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples.

@article{Marahatta2016StableIsotopeDH,
  title={Stable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples.},
  author={Anu Marahatta and Vandana Megaraj and Patrick T McGann and Russell E Ware and Kenneth D R Setchell},
  journal={Clinical chemistry},
  year={2016},
  volume={62 12},
  pages={1593-1601}
}
BACKGROUND Sickle cell anemia (SCA) is a life-threatening blood disorder characterized by the presence of sickle-shaped erythrocytes. Hydroxyurea is currently the only US Food and Drug Administration-approved treatment and there is a need for a convenient method to monitor compliance and hydroxyurea concentrations, especially in pediatric SCA patients. METHODS We describe a novel approach to the determination of hydroxyurea concentrations in dried whole blood collected on DMPK-C cards or… CONTINUE READING

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